After a pitchers' duel between Michael Wacha of St. Louis and Jon Lackey of Boston through the first three innings, Matt Holliday tripled to lead off the fourth and later scored. A David Ortiz two-run homer int he sixth gave the Sox the lead.
Only Ortiz and Dustin Pedroia have been hitting well for the Sox thus far in the World Series, despite the eight run outburst in Game 1. As it would turn out, the two runs off of Ortiz's bat weren't enough for Boston to win.
An errant throw the next half inning by Boston's Craig Breslow began a chain that would allow three Cardinal runners to cross the plate in the top of the 7th. Carlos Beltran, playing in spite of aching ribs, went 2 for 4 with an RBI. After two strong innings by Carlos Martinez, Trevor Rosenthal got the save. The Cardnials won 4-2 to tie the series at one.